The Science

Backed by 25+ years of scientific research

The genesis of VoxNeuro is a scientific breakthrough in the quantitative measurement and assessment of concussions and traumatic brain injuries by Dr. John F. Connolly, an extensively published and world-renowned neuroscientist.

Our proprietary methods include adapted industry-validated neuropsychological & physiological tests with simultaneous electroencephalography (EEG) recording. By leveraging widely used and validated assessment methods and pairing them with EEG, our assessments transform what would be qualitative results from traditional testing into objective, quantifiable measurements of brain function that support informed clinical decision making.

This is achieved through a 1-hour test, with a series of tasks that trigger event related potentials (ERPs) in a patient’s brain, captured by EEG. Each ERP is indicative of a patient’s performance in their core functions: working memory, automatic attention, reactive attention, concentration, language comprehension, and executive function. These impact a patient's well-being and quality of life.

Our reports analyze the patient’s performance, captured through their brain’s electrical activity (example brain wave recording seen in Figure 1), in each core function by comparing their response strength and timing to healthy controls.

Figure 1.

Comparing Methods of Assessing Brain Injury

When an individual suffers a brain injury, whether mild or severe, two types of neurological damage are to be assessed: structural and functional. Structural damage refers to physical damage to the skull and brain; all other symptoms or effects resulting from the injury fall under the category of functional damage. It is important to note that the presence of structural damage does not necessarily imply functional damage, and vice-versa.

Healthcare providers commonly use the following tools to help assess and diagnose brain injuries:

Behavioural and neuropsychological tests: used to measure symptoms and behavioural changes in a patient following an injury.

Traditional neuroimaging: magnetic resonance imaging (MRI) and computed tomography (CT) scans are useful in identifying structural injuries associated with the brain. For example, injuries such as skull fractures, brain tumors, and lesions.

Functional MRI (fMRI) is not yet clinically available, but is starting to be offered through private services. It measures blood flow in the brain and can identify abnormal structural integrity and functional connectivity.

VoxNeuro’s cognitive health assessments are non-invasive and can be used to objectively identify abnormal brain function - objectively confirming a concussion, and pinpoint areas that have been impacted by an injury for customized rehabilitation including working memory, automatic attention, reactive attention, concentration, language comprehension, and executive function.

How are VoxNeuro’s cognitive health assessments different from traditional EEG?

You may have had experience with EEG in the past. It is commonly used to assess seizures and sleep disorders. In some cases, it is also used to try to help assess brain injuries. What is available in most clinics or hospitals are capable of capturing alpha and beta brain waves only, and commonly look at what is called “resting state”.

VoxNeuro’s cognitive health assessments use FDA and Health Canada approved research grade EEG. These machines can capture alpha, beta, theta and delta waves - allowing a much more specific, or deeper, measurement of a patient’s brain waves. We track a patient’s responses to active stimuli instead of resting state.

This can be likened to an electrocardiogram (EKG) that is used to examine the heart’s rate and rhythm to determine its health. You can imagine, you will learn far more about the health of your heart if you test it while being active, as opposed to sitting still in your physician’s office. The same theory applies for testing the brain’s health during resting state, versus active engagement.