The Science


The genesis of VoxNeuro is a scientific breakthrough in the quantitative measurement and assessment of concussions and traumatic brain injuries by Dr. John F. Connolly, an extensively published and world-renowned neuroscientist.
Learn more about the renowned neuroscientist behind the research

Our proprietary methods include adapted industry-validated neuropsychological & physiological tests with simultaneous electroencephalography (EEG) recording. By leveraging widely used and validated assessment methods and pairing them with EEG, we transform what would be qualitative results from traditional testing into objective, quantifiable measurements of brain function that support informed clinical decision making.

This is achieved through a 60-minute test, with a series of tasks that trigger event related potentials (ERPs) in a patient’s brain, captured by EEG. Different ERPs are indicative of a patient’s performance in their core cognitive functions including: executive function, language comprehension, working memory, automatic attention, reactive attention, concentration, information processing, auditory processing, and visual processing. The integrity of these functions are essential for a patient's well-being and quality of life.

Our reports target the patient’s performance, captured through their brain’s electrical activity (example brain wave recording seen in Figure 1), in each core function by comparing their response strength and timing to our healthy control database.


COMPARING METHODS OF ASSESSING BRAIN INJURY

When an individual suffers a brain injury, whether mild or severe, two types of neurological damage are to be assessed: structural and functional. Structural damage refers to physical damage to the skull and brain; all other symptoms or effects resulting from the injury fall under the category of functional damage. It is important to note that the presence of structural damage does not necessarily imply functional damage, and vice-versa.

Healthcare providers commonly use the following tools to help assess and diagnose brain injuries:

1. Behavioural and neuropsychological tests: used to measure symptoms and behavioural changes in a patient following an injury.

2. Traditional neuroimaging: magnetic resonance imaging (MRI) and computed tomography (CT) scans are useful in identifying structural injuries associated with the brain. For example, injuries such as skull fractures, brain tumors, and lesions.


Functional MRI (fMRI) is not yet clinically available, but is starting to be offered through private services. It measures blood flow in the brain and can identify abnormal structural integrity and functional connectivity.

VoxNeuro’s cognitive health assessments are non-invasive and can be used to objectively identify abnormal brain function - objectively confirming a concussion, and pinpoint areas that have been impacted by an injury for customized rehabilitation including working memory, automatic attention, reactive attention, concentration, language comprehension, and executive function.

How are VoxNeuro’s cognitive health assessments different from traditional EEG?

You may have had experience with EEG in the past. It is commonly used to assess seizures and sleep disorders. In some cases, it is also used to help assess severe brain injuries. What is available in most clinics and hospitals is capable of capturing ongoing brain-signals and oscillations passively (e.g., alpha and beta brain waves), and is commonly known as “resting state”.

VoxNeuro’s cognitive health assessments use FDA and Health Canada approved research grade EEG equipment. These systems vastly expand the range of measurable brain activity by enabling direct measurement of the brain's responses to stimulation and cognitive tasks. We track a patient’s active responses to a range of tasks and stimuli instead of resting state.

Our approach can be likened to an electrocardiogram (EKG) that is used to examine the heart’s rate and rhythm to determine its health. You can imagine that you will learn far more about the health of a heart if you test it while being active, as opposed to when a person is sitting still in their physician’s office. The same applies for testing the brain’s health during resting state versus active engagement.